Serum Serotonin Level and its Association with Pain in FMF Patients

Abstract

Abstract

Objective: This study was performed to investigate the serum serotonin levels and the relationship between serotonin levels and pain in Familial Mediterranean Fever (FMF) patients during attack-free period.

Materials and Methods: Fourthy-three FMF patients and 20 healthy controls were included in the study. The clinical and laboratory assessments of FMF patients were performed during an attack-free period. The erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), and serotonin levels were aalyzed.

Results: The ESR, serum CRP, and serotonin levels of the FMF patients and controls were similar during attack-free period. In addition, there was no statistically significantrelationship between serotonin levels and the severity of pain in FMF patients (P>0.05).

Conclusion: The serum serotonin levels seem to be within normal range in FMF patients during attack-free period. Further studies investigating the serotonin levels in FMF patients during attack periods or in those not receiving colchicine therapy are needed.